|
KMID : 1004820110120010011
|
|
Journal of Biomedical Research
2011 Volume.12 No. 1 p.11 ~ p.21
|
|
|
Anti-atherosclerotic Effect of Carnitine in Rabbits
|
|
Park Dong-Sun
Kim Da-Jeong
Kyung Jang-Been
Yang Yun-Hui
Kim Yun-Bae
Choi Ehn-Kyoung
|
|
|
Abstract
|
|
|
|
Effects of carnitine on atherosclerosis and steatosis of hypercholesterolemic rabbits induced by a high-cholesterol diet (HCD) containing 0.5% cholesterol and 2.0% corn oil were investigated. Male New Zealand white rabbits with hypercholesterolemia (blood cholesterol 1,000-1,500 mg/dl) induced by two-week feeding a HCD, were fed a HCD containing 0.008 or 0.075% L-carnitine for an additional eight weeks. Feeding a HCD for 10 weeks resulted in severe atheromatous change, covering 55.7% of the aortic walls, in addition to profound hepatic steatosis. However, carnitine supplementation resulted in recovery of the increased low-density lipoproteins and triglycerides and a decrease in the levels of high-density lipoproteins following HCD feeding, although the increased cholesterol concentration was not potentially attenuated. Notably, carnitine induced a marked reduction of the atheroma area and hepatic lipid accumulation as well as lipid peroxidation. The results of this study indicated that carnitine exerted anti-atherosclerotic and fatty liver-preventing activities through blockade of lipid peroxidation and regulation of lipid metabolism.
|
|
|
KEYWORD
|
|
|
Anti-atherosclerosis, Carnitine, Hypercholesterolemia, Fatty liver, Lipid deposit
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|